Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics.
نویسندگان
چکیده
Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure-activity relationship of such coactivator mimics concerning helix length.
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ورودعنوان ژورنال:
- Chemical communications
دوره 36 شماره
صفحات -
تاریخ انتشار 2009